Production Of Transgenic Animals Notes

A transgenic animal is an animal in which one or more genes have been introduced into its nonreproductive cells.

Production of transgenic animals notes. One favoured method involves the inoculation of the DNA into the pronucleus of a fertilised ovum followed by implantation into pseudo pregnant females. ES cells are obtained from the inner cell mass of a blastocyst. The development of transgenic animals has been part of biotechnology research which has been expanding rapidly.

Due to the controversial concept of cloning and scientific testing on animals there are many questions that revolve around this topic. Genetically modified animals are proving ever more vital in. Transgenic animals are used as tools in research and for the production of recombinant proteins The main applications of transgenic animals are described as follows.

Transgenic animals can be created by manipulating embryonic stem cells. Then they are inserted into a blastocyst and implanted into a hosts uterus to grow normally. The transgenic expression is not only used to breed animals which have specific traits but also to breed animals that are lacking specific genes This technique is called as knockout or gene.

Many procedures have been developed to increase the efficiency of this generally inefficient process. Transgenic animals can be used to produce valuable products. To yield industrial as well as consumer product To research human diseases To produce pharmaceutical products and tissue for implantation.

Milk is the secretion of mammary glands that can be collected frequently without causing any harm to the animal. The first transgenic animal was produced is mice by injecting DNA to mouse embryos then implanting the embryos in female mice. The animals used for transgenic purpose naturally carry the mechanism needed to produce complex protein.

Transgenic animals have the potential of agricultural applications like improved growth rate and carcass composition improved resistance to disease increased milk. Microinjection blastocyst injection and using a retrovirus Nuclear transfers Artificial chromosomes for gene transfer PRODUCTION OF TRANSGENIC ANIMALS THE METHODOLOGY. Advantages of Transgenic Animals.